Plasma lipid transfer proteins
نویسنده
چکیده
The composition of the plasma lipoproteins is continuously modified during their intravascular metabolism, as a result of a dynamic exchange and net transfer of lipids between particles or between particles and cells. Specialized proteins, the plasma lipid transfer proteins, facilitate the transfer and exchange of phospholipids, cholesteryl esters, and triglycerides between the lipoproteins. Although there is little published evidence, plasma lipid transfer proteins can probably also influence the transfer of lipids between lipoproteins and cells.
منابع مشابه
Plasma cholesteryl ester transfer protein.
The plasma lipoproteins are continuously remodeled during their transit through the plasma compartment, owing to the action of lipid metabolizing enzymes and lipid transfer processes. These activities have a major effect on the composition, size, and concentration of the lipoproteins. Lipid transfer processes involving neutral lipids and phospholipids are mediated by specialized plasma proteins...
متن کاملPartitioning of lipid-modified monomeric GFPs into membrane microdomains of live cells.
Many proteins associated with the plasma membrane are known to partition into submicroscopic sphingolipid- and cholesterol-rich domains called lipid rafts, but the determinants dictating this segregation of proteins in the membrane are poorly understood. We suppressed the tendency of Aequorea fluorescent proteins to dimerize and targeted these variants to the plasma membrane using several diffe...
متن کاملMolecular insights into conformational dynamics associated with the open-closed-phosphorylated states of PITPα
Phosphatidylinositol transfer proteins (PITPα) are lipid carrier proteins that are involved in replenishing the phosphatidylinositol lipid molecules on the plasma membranes. Transitions between the open and closed state conformations are necessary steps in the mechanism of lipid transfer by PITPα. The apo (open state) conformation is assumed to occur at the membrane surface during the lipid exc...
متن کاملArabidopsis leaf plasma membrane proteome using a gel free method: Focus on receptor–like kinases
The hydrophobic proteins of plant plasma membrane still remain largely unknown. For example in the Arabidopsis genome, receptor-like kinases (RLKs) are plasma membrane proteins, functioning as the primary receptors in the signaling of stress conditions, hormones and the presence of pathogens form a diverse family of over 610 genes. A limited number of these proteins have appeard in pr...
متن کاملEvaluation of phospholipid transfer protein and cholesteryl ester transfer protein as contributors to the generation of pre beta-high-density lipoproteins.
High-density lipoproteins (HDLs) are considered anti-atherogenic because they mediate peripheral cell cholesterol transport to the liver for excretion and degradation. An important step in this reverse cholesterol-transport pathway is the uptake of cellular cholesterol by a specific subclass of small, lipid-poor apolipoprotein A-I particles designated pre beta-HDL. The two lipid-transfer protei...
متن کامل